Copper is an essential mineral found throughout the body in small amounts, primarily in bones and muscles. 1
As a trace mineral, copper serves as a cofactor for enzymes, facilitating energy production for iron metabolism, connective tissue and red blood cell formation, collagen synthesis, and neurotransmitter production. 1, 2
Copper is essential for the health and maintenance of the immune and nervous systems, as well as for brain and gene development. 3
In general most people consume enough copper in their daily diet, however some people may be at risk of low copper levels:
People who take high doses of zinc supplements or use products, such as denture creams that contain zinc, may be at risk of a copper deficiency. Zinc limits copper absorption. People consuming zinc supplements and products should discuss copper supplementation with their healthcare practitioner. 1, 4 ‡
Those with absorption challenges may be at risk of low copper levels. 1, ‡
Copper bisglycinate is made by binding bivalent copper with two glycine molecules. This ratio of copper to the amino acid glycine increase solubility, encouraging enhanced absorption in the small intestine and bloodstream. ‡
Fully reacted, chelated minerals like copper bisglycinate do not disassociate in the stomach’s acidic environment. Instead, this form of copper remains covalently bonded and properly absorbed and used by the body. ‡
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Benefits of Copper Bisglycinate
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‡These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
1 Copper: Fact Sheet for Health Professionals: National Institutes of Health (Accessed July 11, 2023) https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/
2 Copper: Harvard T.H. Chan School of Public Health (Accessed July 11, 2023) https://www.hsph.harvard.edu/nutritionsource/copper/
3 Copper: Fact Sheet for Consumers: National Institutes of Health (Accessed July 11, 2023) https://ods.od.nih.gov/factsheets/Copper-Consumer/
4 Zinc: Mount Sinai (Accessed July 11, 2023) https://www.mountsinai.org/health-library/supplement/zinc
5 Disilvestro, Robert & Joseph, Elizabeth & Zhang, Wenyi & Raimo, Adrienne & Kim, Young. (2012). A randomized trial of copper supplementation effects on blood copper enzyme activities and parameters related to cardiovascular health. Metabolism: clinical and experimental. 61. 1242-6. 10.1016/j.metabol.2012.02.002. (Accessed July 11, 2023) https://www.researchgate.net/publication/221973562_A_randomized_trial_of_copper_supplementation_effects_on_blood_copper_enzyme_activities_and_parameters_related_to_cardiovascular_health
6 Impact of Copper Limitation on Expression and Function of Multicopper Oxidases (Ferroxidases): Joseph R. Prohaska. Department of Biochemistry and Molecular Biology, University of Minnesota Medical School. (Accessed July 11, 2023) https://advances.nutrition.org/article/S2161-8313(22)00568-3/pdf
7 Mahdavi-Roshan M, Ebrahimi M, Ebrahimi A. Clin Cases Miner Bone Metab. 2015 Jan-Apr;12(1):18-21. doi: 10.11138/ccmbm/2015.12.1.018. PMID: 26136790; PMCID: PMC4469220. (Accessed July 11, 2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469220/
8 The Link Between Copper and Nutrition: Healthline.com (Accessed July 11, 2023) https://www.healthline.com/health/heavy-metal-good-for-you-copper
9 Health Benefits and Risks of Copper: MedicalNewsToday (Accessed July 11, 2023) https://www.medicalnewstoday.com/articles/288165