We start with a pure culture of Saccharomyces cerevisiae, better known as baker’s yeast. Once the yeast has grown in the laboratory, it goes through a fermentation process in which nutrients and desired mineral are added. The mineral is incorporated inside the cells and transformed into a food-form of the element (for example, selenium or chromium). After this step, the yeast is separated from the broth, inactivated, spray dried, and packaged.
Selenomethionine (SeMet) is a single amino acid. It is found naturally in the protein of different foods. However, the SeMet used in supplements is industrially produced.
SelenoExcell® High Selenium Yeast is a whole, inactive cell, with protein structures formed during the fermentation process, which include several selenium compounds, including the amino acid SeMet.
The SELECT Trial clearly established that SeMet administered to the diet of healthy American males fifty years of age and older, does not reduce prostate cancer risk.(1) On the other hand, high selenium yeast, particularly SelenoExcell, shown to be highly effective in the reducing the risk of colon, lung, and prostate cancer in the Nutritional Prevention of Cancer Trail (NPC), and has continued to demonstrate its benefits in many health categories.(2) The most recent study published by Dr. John Richie from Penn State University validates the superiority of SelenoExcell over SeMet by decreasing biomarkers of oxidative stress.(3)
There has been some confusion on this topic. In an interview, Candida infection expert, Dr. Jack Sobel of Wayne State University and the Harper Hospital in Detroit said: “Saccharomyces cerevisiae is a classic example of a non-pathogenic, non-virulent, non-dangerous; non-disease associated microorganism or yeast, while Candida albicans is at the other end of the spectrum.” Making this comparison would be like seeing probiotics (beneficial bacteria like Lactobacillus) in the same category as Salmonella, or E. coli.
In our manufacturing process, the yeast is inactivated (killed) before drying, and test results of the finished product certify the deactivation of the cells. Additionally, depending on the formulation of the supplement or food in which it is included, the amount of yeast is very small and can be prodived upon request.
Brewer’s yeast is also a Saccharomyces cerevisiae strain, but with characteristics that make it more efficient for the conditions of the beer production process. In comparison, it would be like humans living in different climates; same species, but with traits that help them adapt to their environment in the most effective manner.
GTF is the term used to describe the organically bound form of chromium found in nature. Its structure is still under study; however, researchers identify it as a complex of amino acids, and its effect in blood sugar management and lipid profile have been thoroughly studied since the 1950s.(4,5,6,7)
Our products are manufactured in a cGMP certified facility, and Kosher certification is also available. Additionally, the process is Halal compliant. SelenoExcell is further supported by a Letter of No Objection for GRAS Status from the FDA.
The RDA (Recommended Dietary Allowance) and accompanying information for many nutrients, including minerals, can be found in the Supplement Fact Sheets provided by the NIH Office of Dietary Supplements. (4)
Cypress Systems’ products are sold as ingredients to our customers that formulate and manufacture finished dietary supplements and/or food products. You can find specific SelenoExcell products that accommodate your needs at our SelenoExcell website, Where to Buy.
Organically bound (OB) minerals, like SelenoExcell® High Selenium Yeast, are present as you would find them in nature. The yeast cells transform the elements during the fermentation as plants do when taking nutrients from the soil. Organically bound minerals are analogous to the forms found in food, and most of them have shown to have higher bioavailability and lower toxicity compared to the inorganic forms (in the case of selenium, sodium selenite).
A chelated mineral is different. The mineral ion is “attached” to an organic compound, like an amino acid, with bonds that would resemble an encapsulation. The research is not fully clear on the effectiveness of these form of minerals.
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1. Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009; 301(1):39-51.
2. Clark LC, Combs GF, Jr., Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 1996;276(24):1957-63.
3. Richie JP Jr, Das A, Calcagnotto AM, Sinha R, Neidig W, Liao J, Lengerich EJ, Berg
A, Hartman TJ, Ciccarella A, Baker A, Kaag MG, Goodin S, DiPaola RS, El-Bayoumy K. Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Cancer Prev Res (Phila). 2014 Aug;7(8):796-804.
4. National Institutes of Health, Office of Dietary Supplements, Dietary Supplements Fact Sheet, accessed Feb. 1, 2017
5. Weksler-Zangen S, Mizrahi T, Raz I, Mirsky N. Glucose tolerance factor extracted from yeast: oral insulin-mimetic and insulin-potentiating agent: in vivo and in vitro studies. Br J Nutr. 2012 Sep;108(5):875-82.
6. Racek, J., Sindberg, C.D., Moesgaard, S. et al. Biol Trace Elem Res (2013) 155: 1.
7. Mirsky N, Cohen R, Eliaz A, Dovrat A. Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast. Experimental Biology and Medicine. 2016;241(8):817-829.